Effects of intermittent fasting on liver physiology and metabolism in mice

A broad spectrum of health benefits from intermittent fasting have been reported in studies on animal models and human subjects. However, the underlying mechanisms these beneficial effects remain largely elusive. The present study aimed to explore potential mode action mouse with a focus liver. C57BL/6 mice were subjected or ad libitum feeding as controls. It was determined that 12 h daily for 30 days significantly reduced cumulative food intake compared feeding. Fasting resulted liver mass but only had minimal effect bodyweight. by not reversed subsequent refeeding days. Among measured blood biochemical parameters, levels glucose decreased, while alkaline phosphatase increased mice. Of note, targeted metabolic profiling revealed global elevation metabolites livers These molecules included adenosine triphosphate, nicotinamide adenine dinucleotide phosphate (NADP), NADP succinate, which are essentially involved citric acid cycle oxidative phosphorylation. Thus, it concluded one month weight mice, is associated enhanced metabolism.